Question: What Is Podocyte Cell?

What is Vasa recta in nephron?

The vasa recta capillaries are long, hairpin-shaped blood vessels that run parallel to the loops of Henle.

The hairpin turns slow the rate of blood flow, which helps maintain the osmotic gradient required for water reabsorption.

Illustration of the vasa recta which run alongside nephrons..

What are podocytes made of?

Podocytes are cells in the Bowman’s capsule in the kidneys that wrap around capillaries of the glomerulus. Podocyte cells make up the epithelial lining of Bowman’s capsule, the third layer through which filtration of blood takes place.

Do podocytes have a nucleus?

Podocytes show a flat cytoplasm with a visible rise containing the nucleus. They have a well-developed Golgi apparatus, abundant endoplasmic reticulum, and many mitochondria and lysosomes. The cytoplasm sends many tiny finger-like protrusions that wrap the basal lamina of capillaries.

Where are podocyte cells found?

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries and that neighbor cells of the Bowman’s capsule.

What is the purpose of podocytes?

Podocytes play an important role in glomerular function. Together with endothelial cells of the glomerular capillary loop and the glomerular basement membrane they form a filtration barrier. Podocytes cooperate with mesangial cells to support the structure and function of the glomerulus.

What’s the glomerulus?

The glomerulus is a tuft of capillaries located within Bowman’s capsule within the kidney. … Blood enters the capillaries of the glomerulus by a single arteriole called an afferent arteriole and leaves by an efferent arteriole.

What is the shape of nephron podocytes?

It transitions onto the glomerular capillaries in an intimate embrace to form the visceral layer of the capsule. Here, the cells are not squamous, but uniquely shaped cells (podocytes) extending finger-like arms (pedicels) to cover the glomerular capillaries (Figure 1). Figure 1.

Why is it called Bowman’s capsule?

Bowman’s capsule is named after Sir William Bowman (1816–1892), a British surgeon and anatomist. However, thorough microscopical anatomy of kidney including the nephronic capsule was first described by Ukrainian surgeon and anatomist from the Russian Empire, Prof.

What is the Bowman’s capsule?

Bowman’s capsule is a part of the nephron that forms a cup-like sack surrounding the glomerulus. Bowman’s capsule encloses a space called “Bowman’s space,” which represents the beginning of the urinary space and is contiguous with the proximal convoluted tubule of the nephron.

Where is the Bowman’s capsule?

The Bowman’s capsule is found in the outer part of the kidney, the cortex. Essentially, the capsule is a sealed, expanded sac at the end of the tubule, the rest of which elongates into a twisted and looped tubule in which urine is formed. Figure 9.2. Structural overview of a nephron, the functional unit of the kidney.

Do podocytes undergo mitosis?

Under pathological conditions, podocytes may undergo mitosis, but not cell division. Exceptions to this rule are collapsing glomerulopathies (CGs), including HIV-associated nephropathy (HIVAN) and idiopathic CG, where podocytes undergo a dysregulation of their differentiated phenotype and proliferate.

What are the cells present in the inner walls of Bowman’s capsule?

The parietal epithelium of Bowman’s capsule consists of squamous epithelial cells resting on a basement membrane (see Figs. 1.5 and 1.6). The flat cells are filled with bundles of actin filaments running in all directions.

What type of cells are podocytes?

There are therefore four resident cell types in the glomerulus: endothelial cells, mesangial cells, parietal epithelial cells of Bowman’s capsule, and podocytes (Figure 1a). Podocytes are pericyte-like cells with a complex cellular organization consisting of a cell body, major processes, and foot processes (FPs).

What is podocyte injury?

The visceral glomerular epithelial cell, also called podocyte, is a terminally differentiated cell that lines the outer aspect of the glomerular basement membrane (GBM). It therefore forms the final barrier to protein loss, which explains why podocyte injury is typically associated with marked proteinuria.

What are mesangial cells and podocytes?

Mesangial cells and their matrix form the central stalk of the glomerulus and are part of a functional unit interacting closely with endothelial cells and podocytes. Alterations in one cell type can produce changes in the others.